Job Title

About BecomingBecoming is building Developmental Intelligence: AI for predicting how organisms change over time.Most experimental systems fail when metabolic demands become too high. We are building systems that don't - enabling sustained, controllable biological processes over long time horizons so that development, adaptation, and failure can be observed, perturbed, and predicted.Physiology is central to this effort. Without stable, well-characterized physiological function, long-horizon prediction is impossible.The RoleWe are hiring a Developmental Systems Lead to own making externally sustained developmental systems run stably, repeatably, and predictably over days to weeks.This role is for someone who thinks in systems, not endpoints - someone who understands how transport, metabolism, signaling, mechanics, and homeostasis interact over time. You will lead the design and operation of systems that integrate perfusion, physiology, sensing, actuation, and closed-loop control to sustain and perturb development in ways that generate meaningful, causal data.This is a high-agency role. You will be expected to define measurements, interpret dynamics, and drive improvements in system-level function.What You'll OwnEnd-to-end responsibility for externally sustained developmental systems operating over days to weeksDefinition of what "success" means beyond "alive," including how stability, drift, and failure are measured over timeIdentification, characterization, and mitigation of long-horizon failure modes (e.g., drift, inflammation, hemolysis, interface breakdown)Design and refinement of closed-loop control strategies for complex biological systemsIntegration of perfusion hardware, sensors, and control software into durable platformsDecisions about when systems are sufficiently stable to perturb, compare, and learn fromClose collaboration with developmental biology, hardware, and ML / modeling teamsBuilding systems that improve with iteration, not systems that require constant manual expert interventionWho You AreYou are someone who:Operates with high agency - you identify what needs to be measured and whyTakes ownership of outcomes, not just data collectionBrings high energy to complex, dynamic biological systemsActs with high integrity - you are honest about uncertainty, limits, and tradeoffsCommunicates directly and clearly, especially when systems are not behaving as expectedIs self-aware about your strengths and gaps, proactively fills them and open to feedbackThinks like a systems integrator, not a siloed specialistIs comfortable working where physiology, engineering, and modeling intersectRequirementsRequiredDeep, hands-on experience with long-running biological or physiological systems (days+, not hours)PhD or equivalent experience in physiology, engineering, or a related fieldExperience with several of the following:Perfusion systems involving blood or blood analogsHemodynamics, flow, pressure, and shear - and their biological consequencesInflammation, coagulation, hemolysis, or endothelial failure in sustained systemsClosed-loop control of noisy, drifting systemsReal-time instrumentation and sensing in biological environmentsDiagnosing failure modes that emerge gradually, not catastrophicallyAbility to work fluently with developmental biologists and/or physiologistsAt least 1 year of industry or applied systems experienceStrong SignalsBackground in perfusion, ECMO, organ support, or normothermic preservationPhysiology-driven systems engineering experienceExperience with complex robotics or control systems operating in irreversible environmentsHistory of systems that failed - and improved because of itBenefitsCompetitive salary and meaningful equityFull benefitsHigh-trust, high-ownership environmentRapid growth in scope and responsibility